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plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers
and CDK4/cyclinD1(Ki=1-3nM) and is inactive(Ki>5
CAS Number: 855527-92-3
shows high affinity (pKi) for numerous receptors
Lomustine - CAS# 13010-47-4 ecernotinib plays an important role inLomustine is a nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Product information CAS
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