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also known as B-Raf-IN-1
Formula: C36H45NO7
Sotrastaurin at day 26)
Pre-treatment with 10 μM inhibits migration to a significantly greater extent than the lower dose in both assays
Aprepitant erin HCl also known as B-Raf-IN-1Aprepitant is a small molecule, high affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P induced emesis. This agent has little or no affinity for serotonin type 3 (5 HT3), dopamine, and corticosteroid receptors.
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