C-178 Catalog No.:M17037-C InChi: InChI=1S/C20H20N4O4/c1-11-4-5-13(14-15(11)27-10-20(14)6-7-20)28-17-21-8-12(9-22-17)24-16(25)19(2

InChi: InChI=1S/C20H20N4O4/c1-11-4-5-13(14-15(11)27-10-20(14)6-7-20)28-17-21-8-12(9-22-17)24-16(25)19(2

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma

CCCC(=O)NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1OC(=O)CCC

InChi: InChI=1S/C28H33NO3/c1-21(2)26(30)31-20-12-6-5-11-19-29-24-15-9-8-14-23(24)27(3

C-178 Catalog No.:M17037-C InChi: InChI=1S/C20H20N4O4/c1-11-4-5-13(14-15(11)27-10-20(14)6-7-20)28-17-21-8-12(9-22-17)24-16(25)19(2C 178 is a potent and selective covalent inhibitor of STING. C 178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. Product information CAS Number: 329198 87 0 Molecular Weight: 322. 27 Formula: C17H10N2O5 Chemical Name: 5 nitro N {8 oxatricyclo[7. 4. 0. 0,]trideca 1(13),2,4,6,9,11 hexaen 5 yl}furan 2 carboxamide Smiles: [O ][N+](=O)C1=CC=C(O1)C(=O)NC1C=C2OC3=CC=CC=C3C2=CC=1 InChiKey: