A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 Catalog No.:M60249-10S Novel small molecule glucagon-like peptide-1

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets

Daminozide was used at 10-20 µM final concentration in vitro and in cellular assays

916232-21-8

(1977) J Endocrinol

A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 Catalog No.:M60249-10S Novel small molecule glucagon-like peptide-1A01, CAS No. 1007647 73 5, is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3. 7 nM. It attenuates Smurf1 mediated Smad 1 5 degradation and enhances BMP signaling. It also potentiates BMP 2 induced osteoblastic activity in C2C12 myoblasts and MC3T3 E1 osteoblast precursor cells. Product information CAS Number: 1007647 73 5 Molecular Weight: 512. 93 Formula: C22H20ClF3N4O3S Chemical Name: (4 ((4 chloro 3