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Formula: C35H46FN5O9S
CAS Number: 1092578-46-5
Molecular Weight: 784
Epigenetics Chromatin
NVP-TAE 226 - CAS# 761437-28-9 hlorobenzyl)-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride Formula: C35H46FN5O9STAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF IR with potential anticancer activity. TAE226 can block FAK and IGF IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration dependent decrease in cellular proliferation with an associated G(2) cell cycle
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