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RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity
Smiles: CC(C)(C)OC(=O)CN1CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1
is conjugated to the lysines on trastuzumab yielding “linker-less” ADC
Formula: C19H23NO8
Dasatinib monohydrate - CAS# 863127-77-9 isandrin C RK-33 impairs radiation-induced DNA damageDasatinib (BMS 354825) monohydrate is a highly potent, ATP competitive, orally active dual Src Bcr Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr Abl, respectively. Dasatinib monohydrate inhibits Bcr Abl and Src with IC50s of <1. 0 nM and 0. 5 nM, respectively. Dasatinib monohydrate also induces apoptosis and autophagy. Product information CAS Number: 863127 77 9 Molecular Weight: 506. 02 Formula:
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