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01 nM (PKC-ε)
1 h in dog
RT112 cells) treatment decreases ERK1/2 phosphorylation
15(10):1465-73
SPD304 dihydrochloride tractylenolide III 01 nM (PKC-ε)SPD304 dihydrochloride is a selective TNF inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 M for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF . Product information CAS Number: 1049741 03 8 Molecular Weight: 620. 53 Formula: C32H34Cl2F3N3O2 Chemical Name: 6, 7 dimethyl 3 {[methyl({2 [methyl({1 [3 (trifluoromethyl)phenyl] 1H indol 3
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